Gut Psychology is the most researched dietary program created specifically for mental health.

Gut Psychology Research & ReferencesThe Gut Psychology program aims to provide you with a foundation in understanding how your health impacts your mood. While, as you see, research well supports the claims made in this program, truthfully the “proof is in the pudding.” The more strictly you stick to the recommendations made in Modules 1, 2, 3 and 4, the better your results will be.

Listed below, are fifty research articles that Dr. Cain used to support the foundation for the Gut Psychology program. This by no means represents a completely exhaustive list, but will give you an glimpse of the foundation of the Gut Psychology data.

In addition to clinical research articles, Dr. Cain also has over a decade of study in mental health. Gut Psychology is a product that contains data extrapolated from both research, as well as data from Dr. Cain’s own medical and clinical experience.

We encourage you to take the tools that you will garner from this program and make it your own. Find recipes that work for you and your family. Experiment with ingredients that you love and great creative. Do your own research. Following a Gut Psychology diet does not mean that you have to give up the foods that you enjoy, but rather to find a way to balance them in order to balance your mood.


(1) Your Backup Brain | Psychology Today | Dan Hurley Retrieved from: on August 30th, 2014.

(2) Hadhazy, A. (2010, February 12). Think Twice: How the Gut’s “Second Brain” Influences Mood and Well-Being. Retrieved from: on September 13, 2014.

(3) Intestinal Flora and Mental Health | Scott Mendelson, M.D. Retrieved from: on August 23, 2014.

(4) More Evidence Linking Diet, Gut Microbes, Moods | Mad In America. Retrieved from: on August 23, 2014.

(5) Gratzer, Walter. “5. Light on sweetness: the discovery of aspartame”. Eurekas and Euphorias: The Oxford Book of Scientific Anecdotes. Oxford University Press. pp. 32–. ISBN 978-0-19-280403-7.

(6) Brown, H. The Other Brain Also Deals With Many Woes. Retrieved from: on July 7,

(7) EatWILD: Getting Wild Nutrition from Modern Food. November 2002. Retrieved from on July 7, 2014.

(8) Kobylewski, S., & Jacobson, M. (2012). Toxicology of food dyes. International Journal of Occupational and Environmental Health, 18(3), 220-246.

(9) Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., … Collins, S. (2011). The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice. Gastroenterology, 141(2), 599-609.e3. Retrieved September 4, 2014, from

(10) Sathyanarayana Rao, T., Asha, M., Ramesh, B., & Jagannatha Rao, K. (2008). Understanding Nutrition, Depression And Mental Illnesses. Indian Journal Of Psychiatry, 50(2), 77-82. Retrieved September 4, 2014, from

(11) Mercola, J. 2014. Fascinating Facts You Never Knew About the Human Brain. Retrieved from on June 7, 2014.

(12) Choosing the right cooking oil, retrieved from on July 7, 2014.

(13) WebMD. Types of Fats – Topic Overview. Retrieved from on July 7, 2014.

(14) Hinz M, Stein A, Uncini T.. Validity of urinary monoamine assay sales under the “spot baseline urinary neurotransmitter testing marketing model”. Int J Nephrol Renovasc Dis. 2011;4:101-13. doi: 10.2147/IJNRD.S22783. Epub 2011 Jul 20. Retrieved from

(15) Stanford, S.C. Function and pharmacology of monoamine neurotransmitters. Reader in Experimental Psychopharmacology. University College London (UCL) 199-2014. Retrieved from & Aug 13, 2014.

(16) Mansouri-Attia, N., James, R., Ligon, A., Li, X., & Pangas, S. (2014). Soy Regulates JGCT Progression. Biology of Reproduction, 27-27. Retrieved September 3, 2014, from

(17) Kaplan, A. (2010, November 30). Statins, Cholesterol Depletion—and Mood Disorders: What’s the Link? Retrieved September 5, 2014, from—and-mood-disorders-what’s-link

(18) Innis, S. (2007). Dietary (n-3) Fatty Acids and Brain Development. The Journal of Nutrition, 137(4), 855-859. Retrieved September 5, 2014, from

(19) Elrich NMD, S. (2011, May 10). Omega-3 fatty acids. Retrieved September 5, 2014, from

(20) LaBuda CJ1, Hale RL. Anxiety in mice following acute aspartame and ethanol exposure. Alcohol. 2000 Jan;20(1):69-74. Retrieved on September 5, 2014, from

(21) Lindseth GN, Coolahan SE, Petros TV, Lindseth PD. Neurobehavioral effects of aspartame consumption. Res Nurs Health. 2014 Jun;37(3):185-93. doi: 10.1002/nur.21595. Epub 2014 Apr 3. Retrieved on September 4, 2013 from

(22) Lima CB, Soares Gde S, Vitor SM, et al, Neonatal treatment with monosodium glutamate lastingly facilitates spreading depression in the rat cortex. Life Sci. 2013 Sep 17;93(9-11):388-92. doi: 10.1016/j.lfs.2013.07.009. Epub 2013 Jul 18. Retrieved on September 4, 2014 from

(23) Quines, CB, Rosa, SG, Da Rocha, JT et al. Monosodium glutamate, a food additive, induces depressive-like and anxiogenic-like behaviors in young rats. Life Sci. 2014 Jun 27;107(1-2):27-31. doi: 10.1016/j.lfs.2014.04.032. Epub 2014 May 5. Retrieved on September 4, 2014 from

(24) Riveros MJ, Parada A, Pettinelli P. Fructose consumption and its health implications; fructose malabsorption and nonalcoholic fatty liver disease. Nutr Hosp. 2014 Mar 1;29(3):491-9. doi: 10.3305/nh.2014.29.3.7178. Retrieved on September 4, 2014 from

(25) Hitti, M. Mercury in High-Fructose Corn Syrup? WebMD Health News, January 27, 2009.. Retrieved on September 4, 2014 from

(25.2) Magee, E. (2009, January 28). Sugar Shockers: Foods Surprisingly High in Sugar. Retrieved September 13, 2014, from

(26) Mansouri-Attia N, James R, Ligon A, Li X, Pangas SA. Soy Promotes Juvenile Granulosa Cell Tumor Development in Mice and in the Human Granulosa Cell Tumor-Derived COV434 Cell Line. Biol Reprod. 2014 Aug 27. pii: biolreprod.114.120899. Retreived on September 4, 2014 from

(27) Chen, J., University of California, Los Angeles (UCLA), Health Sciences (2012, May 15). This is your brain on sugar: Study in rats shows high-fructose diet sabotages learning, memory. ScienceDaily. Retrieved May 16, 2012, from Retrieved from September 5, 2014.

(28) Zielinski, G. Lesser known causes of anxiety. Northwest Functional Nuerology.(2012, December 8). Retrieved from on September 5, 2014.

(29) Deans M.D., E. Do Carbs Make You Crazy. Evolutionary Psychiatry: The hunt for evolutionary solutions to contemporary mental health problems. (2012, March 1). Retrieved from on September 5, 2014.

(30) Scalbert, Augunstin, Johnson, T., Ian, Saltmarsh, Mike (2005). Polyphenols: Antioxidants and beyond. (2005). The American Journal of Clinical Nutrition, 81(1), 2155-2175. Retrieved September 9, 2014, from

(31) Berk, M., Williams, L., Jacka, F., O’Neil, A., Pasco, J., Moylan, S., … Maes, M. (2013). So depression is an inflammatory disease, but where does the inflammation come from? BMC Medicine, 11(200). Retrieved September 9, 2014, from

(32) Flatow, Ira. Not-So-Sweet Side Effects of Artificial Sweeteners. NPR: Science Friday. 2014. Retrieved on September 11, 2014 from

(33) Tynan, R., Weidenhofer, J., Hinwood, M., Cairns, M., Day, T., & Walker, F. (2012). A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia. Brain, Behavior, and Immunity, 26(3), 469-479. Retrieved September 9, 2014, from

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(35) Oxygen, antioxidants and brain dysfunction. (1993). Yonsei Medical Journal, 34(1), 1-10. Retrieved September 9, 2014, from

(36) Naish, J. Happy pills can give you digestive problems and make you MORE depressed. Retrieved from on September 9, 2014

(37) Not-So-Sweet Side Effects of Artificial Sweeteners, 2014 NPR, Science Friday. Retrieved from on September 10, 2014.

(38) MedlinePlus Trusted Health Information For You. Amino Acids. Us. National Library of Medicine. National Institute of Health. Retrieved from on November 1, 2014

(39) McDougall, J. Plant Foods Have a Complete Amino Acid Composition. Circulation, 2002. The American Heart Association. Retrieved from on November 1, 2014

(40) Mayo Clinic. Meatless meals: The benefits of eating less meat. Healthy Lifestyle Nutrition and Healthy Eating. Retrieved from on November 1, 2014

(41) Rea, W.J. EHC-D. Rotational Diet. Environmental Health Center- Dallas. Retrieved from: on November 1, 2014

(42) Michaelsson, K. Wolk, A. et al. Milk intake and risk of mortality and fractures in women and men: cohort studies. BMJ 2014;349:g6015. Retrieved from

(43) Chang CY1, Ke DS, Chen JY. Essential fatty acids and human brain. Acta Neurol Taiwan. 2009 Dec;18(4):231-41. Retrieved from on November 1, 2014

(44) Kohlboeck, G., Sausenthaler, S., et al. Food intake, diet quality and behavioral problems in children: results from the GINI-plus/LISA-plus studies. Ann Nutr Metab. 2012;60(4):247-56. doi: 10.1159/000337552. Epub 2012 Jun 1. Retrieved from on November 1, 2014.

(45) Gillman, MW, Cupples, LA., et al. Margarine intake and subsequent coronary heart disease in men. Epidemiology. 1997 Mar;8(2):144-9. Retrieved from on November 1, 2014.

(46) Chattopadhyay , A., 24 Amazing Benefits Of Almond Oil For Skin, Hair And Health. November 12, 2014. Retrieved from on November 13, 2014.

(47) Real Simple Dot Com. Olive-Oil Buying Checklist. Retrieved from on November 1, 2014

(48) Gunnars, K. Healthy Cooking Oils– The Ultimate Guide. Authority Nutrition- An Evidence Based Approach. Retreived from on November 1, 2014.

(49) Nanri, A., et al. “Dietary Patterns and Depressive Symptoms Among Japanese Men and Women.” European Journal of Clinical Nutrition 2010; doi: 10.1038/ejcn.2010.86. Retrieved from on November 10, 2014.

(50) Pase, M.P, Scholey, A.B., et al. Cocoa polyphenols enhance positive mood states but not cognitive performance: A randomized, placebo-controlled trial. 2012. Journal of Psychopharmacology 0(0) 1– 8. DOI: 10.1177/0269881112473791